Quadrivalent Vaccine

DIPHTHERIA, TETANUS, PERTUSSIS AND HEPATITIS B VACCINE ADSORBED

Diphtheria, Tetanus, Pertussis and Hepatitis B Vaccine Adsorbed (SII Q-VAC) as supplied by Serum Institute of India Ltd., is sterile, opaque, uniform suspension of diphtheria toxoid, tetanus toxoid, killed Bordetella pertussis bacilli and Hepatitis B surface antigen adsorbed on aluminum gel and suspended in isotonic sodium chloride solution. Surface antigen of the Hepatitis B virus (HBV) is obtained by culturing genetically engineered Hansenula polymorpha yeast cells having the surface antigen gene of the Hepatitis B virus. The Hepatitis-B surface antigen (HBsAg) expressed in the cells of Hansenula polymorpha is purified through several chemical steps using recombinant DNA procedures. Thiomersal is added as preservative.
Each dose of 0.5 ml contains :
Diphtheria Toxoid > 20 Lf to < 30 Lf
Tetanus Toxoid > 5 Lf to < 25 Lf
B. pertussis (whole cell) > 4 IU
HBsAg (rDNA) > 10 mcg
Al+++< 1.25 mg
Preservative: Thiomersal < 0.01%

DTP-HB vaccine does not prevent Hepatitis caused by other agents different from HBV (as virus A, C and E) but it is considered effective in preventing Hepatitis caused by the delta agent.

DTP-HB Vaccine Adsorbed is indicated for the active immunization of infants, at or above the age of 6 weeks of birth and of children through 6 years of age against Diphtheria, tetanus, whooping cough and Hepatitis B. In young children the EPI recommends as many antigens as possible to be administered at a single visit. The combined vaccine can be given safely and effectively at the same time as BCG, Measles and Polio vaccines (OPV and IPV), Hib, Yellow Fever vaccines and Vitamin A supplementation.